APPENDIX 1E A Convenient Stereochemical Notation for P-Chiral Nucleotide Analogs
Published Online: 1 MAR 2007
Copyright © 2007 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Nucleic Acid Chemistry
How to Cite
Sobkowski, M., Stawinski, J. and Kraszewski, A. 2007. A Convenient Stereochemical Notation for P-Chiral Nucleotide Analogs. Current Protocols in Nucleic Acid Chemistry. 28:1E:A.1E.1–A.1E.16.
- Published Online: 1 MAR 2007
- Published Print: MAR 2007
The DP/LP convention is a stereochemical notation for P-chiral nucleotide analogs and related compounds. In contrast to the absolute RP/SP notation, the DP/LP system is based on a geometrical relationship between substituents in a dinucleoside monophosphate skeleton. The DP/LP notation is a convenient alternative to the RP/SP notation for stereochemical correlation analysis of physical, chemical, and biological properties of nucleotide and oligonucleotide analogs bearing any type of tri- or tetra-coordinated phosphorus moiety.
- nucleotide analogs;
- DP/LP notation