Appendix

APPENDIX 1E A Convenient Stereochemical Notation for P-Chiral Nucleotide Analogs

  1. Michal Sobkowski1,
  2. Jacek Stawinski2,
  3. Adam Kraszewski1

Published Online: 1 MAR 2007

DOI: 10.1002/0471142700.nca01es28

Current Protocols in Nucleic Acid Chemistry

Current Protocols in Nucleic Acid Chemistry

How to Cite

Sobkowski, M., Stawinski, J. and Kraszewski, A. 2007. A Convenient Stereochemical Notation for P-Chiral Nucleotide Analogs. Current Protocols in Nucleic Acid Chemistry. 28:1E:A.1E.1–A.1E.16.

Author Information

  1. 1

    Institute of Bioorganic Chemistry, Poznan, Poland

  2. 2

    Stockholm University Stockholm, Sweden and Institute of Bioorganic Chemistry, Poznan, Poland

Publication History

  1. Published Online: 1 MAR 2007
  2. Published Print: MAR 2007

Abstract

The DP/LP convention is a stereochemical notation for P-chiral nucleotide analogs and related compounds. In contrast to the absolute RP/SP notation, the DP/LP system is based on a geometrical relationship between substituents in a dinucleoside monophosphate skeleton. The DP/LP notation is a convenient alternative to the RP/SP notation for stereochemical correlation analysis of physical, chemical, and biological properties of nucleotide and oligonucleotide analogs bearing any type of tri- or tetra-coordinated phosphorus moiety.

Keywords:

  • stereochemistry;
  • configuration;
  • P-chiral;
  • nucleotide analogs;
  • DP/LP notation