UNIT 11.15 Introduction to Peptide Synthesis

  1. Gregg B. Fields

Published Online: 1 AUG 2002

DOI: 10.1002/0471142727.mb1115s59

Current Protocols in Molecular Biology

Current Protocols in Molecular Biology

How to Cite

Fields, G. B. 2002. Introduction to Peptide Synthesis. Current Protocols in Molecular Biology. 63:IV:11.15:11.15.1–11.15.9.

Author Information

  1. Florida Atlantic University, Boca Raton, Florida

Publication History

  1. Published Online: 1 AUG 2002
  2. Published Print: JUL 2002


This overview presents a review of classical and current solid-phase peptide synthesis techniques. Peptide synthesis has become a more practical part of present-day scientific research following the advent of solid-phase techniques, and has practical commercial and scientific implications. This unit provides information on solid-phase peptide-synthesis methodology, offering descriptions of different supports, coupling reagents, and practical approaches to the synthesis of modified residues and structures. It also presents information concerning protein synthesis and the purification and analysis of synthetic peptides. This methodology has great implications for the design of synthetic peptides to serve in antibody production.