UNIT 19.4 Protein Databases on the Internet

  1. Dong Xu1,
  2. Ying Xu2

Published Online: 1 NOV 2004

DOI: 10.1002/0471142727.mb1904s68

Current Protocols in Molecular Biology

Current Protocols in Molecular Biology

How to Cite

Xu, D. and Xu, Y. 2004. Protein Databases on the Internet. Current Protocols in Molecular Biology. 68:19.4:19.4.1–19.4.15.

Author Information

  1. 1

    Digital Biology Laboratory, University of Missouri–Columbia, Columbia, Missouri

  2. 2

    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia

Publication History

  1. Published Online: 1 NOV 2004
  2. Published Print: OCT 2004

This is not the most recent version of the article. View current version (1 JAN 2012)


Protein databases have become a crucial part of modern biology. Huge amounts of data for protein structures, functions, and particularly sequences are being generated. Searching databases is often the first step in the study of a new protein. Comparison between proteins and between protein families in databases provides information about the relationship between proteins within a genome or across different species, and hence offers much more information than can be obtained by studying only an isolated protein. In addition, secondary databases derived from experimental databases are also widely available. These databases reorganize and annotate the data or provide predictions. The use of multiple databases often helps researchers understand the structure and function of proteins. Although some protein databases are widely known, they are far from being fully utilized in the protein science community. This unit provides a starting point for readers to explore the potential of protein databases on the Internet.