Unit

UNIT 29A.2 Minimizing Variation Due to Genotype and Environment

  1. Carmen A. Argmann1,
  2. Johan Auwerx2

Published Online: 1 FEB 2006

DOI: 10.1002/0471142727.mb29a02s73

Current Protocols in Molecular Biology

Current Protocols in Molecular Biology

How to Cite

Argmann, C. A. and Auwerx, J. 2006. Minimizing Variation Due to Genotype and Environment. Current Protocols in Molecular Biology. 73:A:29A.2:29A.2.1–29A.2.3.

Author Information

  1. 1

    Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France

  2. 2

    Institut de Génétique et de Biologie Moléculaire et Cellulaire and Institut Clinique de la Souris, Illkirch, France

Publication History

  1. Published Online: 1 FEB 2006
  2. Published Print: JAN 2006

Abstract

Mouse models are increasingly popular tools to study and characterize the molecular and physiological bases for human diseases. Due to the readily available genetic tools to construct mouse models of complex diseases, the flow of efficient and vigilant mouse phenotyping has now become the bottleneck in mouse functional genomics. This unit addresses the importance of minimizing and defining confounding genetic and environmental sources of variability.

Keywords:

  • genotype;
  • phenotype;
  • environment;
  • strain variation;
  • genetic background