UNIT 1.2 Managing Immunocompromised Animals

  1. John Donovan1,
  2. Patricia Brown2

Published Online: 1 MAY 2007

DOI: 10.1002/0471142735.im0102s77

Current Protocols in Immunology

Current Protocols in Immunology

How to Cite

Donovan, J. and Brown, P. 2007. Managing Immunocompromised Animals. Current Protocols in Immunology. 77:I:1.2:1.2.1–1.2.5.

Author Information

  1. 1

    Wyeth Research, Collegeville, Pennsylvania

  2. 2

    National Institutes of Health, Bethesda, Maryland

Publication History

  1. Published Online: 1 MAY 2007
  2. Published Print: MAY 2007


This unit describes some commonly used methods for maintaining immunocompromised rodents, specifically mice, to prevent infections from adventitious pathogens. The basic protocol describes the microisolation housing unit, while alternate procedures cover individually ventilated isolator housing, laminar-flow rack housing, flexible-film isolator housing, and barrier facility housing.