UNIT 1.4 Anesthesia

  1. John Donovan1,
  2. Patricia Brown2

Published Online: 1 MAY 2001

DOI: 10.1002/0471142735.im0104s27

Current Protocols in Immunology

Current Protocols in Immunology

How to Cite

Donovan, J. and Brown, P. 2001. Anesthesia. Current Protocols in Immunology. 27:I:1.4:1.4.1–1.4.5.

Author Information

  1. 1

    Rhone-Poulenc Rorer, Collegeville, Pennsylvania

  2. 2

    National Cancer Institute, Bethesda, Maryland

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: SEP 1998


Anesthetic agents are used in laboratory animals to prevent pain or distress due to an experimental procedure or for restraint to facilitate a technically difficult procedure. This unit provides three basic protocols: injectable anesthesia for mouse, rat, and hamster; inhalant anesthesia using methoxyflurane for mouse, rat, and hamster; and injectable anesthesia using ketamine/xylazine for rabbit. An Alternate Protocol describes sedation using butorphanol/acetylpromazine in the rabbit. The Commentary further describes and compares these methods of anesthesia for various applications.