UNIT 6.12 Biological Responses to Chemokine Superfamily Members

  1. Dennis D. Taub,
  2. Eric Schaffer

Published Online: 1 MAY 2001

DOI: 10.1002/0471142735.im0612s38

Current Protocols in Immunology

Current Protocols in Immunology

How to Cite

Taub, D. D. and Schaffer, E. 2001. Biological Responses to Chemokine Superfamily Members. Current Protocols in Immunology. 38:6.12:6.12.1–6.12.32.

Author Information

  1. National Institute on Aging, NIH, Washington, D.C.

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: AUG 2000


A detailed summary of all the chemokine subfamily members including alternative names, receptor-ligand pairs, receptor cellular distribution, and leukocyte responsiveness is presented here along with assays to measure the biological activities of chemokines on each of the major leukocyte subsets (i.e., microchemotaxis chambers, fluorescence-based assays, use of nitrocellulose filters and membranes coated with extracellular matrix proteins, cellular adhesion assays, mobilization of intracellular free calcium, actin polymerization, degranulation assays, and the use of chemokine receptor-specific antibodies in flow cytometric analysis and radiolabeled chemokine binding assays).