UNIT 7.36 In Vitro Models of Human T Cell Anergy
Published Online: 1 MAR 2005
Copyright © 2005 by John Wiley & Sons, Inc.
Lab Protocol Title
Current Protocols in Immunology
How to Cite
Appleman, L. J. and Boussiotis, V. 2005. In Vitro Models of Human T Cell Anergy. Current Protocols in Immunology. 65:IV:7.36:7.36.1–7.36.12.
- Published Online: 1 MAR 2005
- Published Print: FEB 2005
T cell anergy (acquired unresponsiveness) is an important mechanism for tolerance of self antigens. Human helper T cell clones rendered anergic in vitro are valuable tools for studying the molecular mechanisms of T cell tolerance. This unit outlines the induction and assessment of anergy in human CD4+ helper T cell clones that are reactive against MHC class II alloantigens.