Unit

UNIT 9.1 Introduction to Peptide Synthesis

  1. Gregg B. Fields

Published Online: 1 MAY 2002

DOI: 10.1002/0471142735.im0901s47

Current Protocols in Immunology

Current Protocols in Immunology

How to Cite

Fields, G. B. 2002. Introduction to Peptide Synthesis. Current Protocols in Immunology. 47:9.1:9.1.1–9.1.9.

Author Information

  1. Florida Atlantic University, Boca Raton, Florida

Publication History

  1. Published Online: 1 MAY 2002
  2. Published Print: FEB 2002

Abstract

A number of synthetic peptides are significant commercial or pharmaceutical products, ranging from the dipeptide sugar-substitute aspartame to clinically used hormones, such as oxytocin, adrenocorticotropic hormone, and calcitonin. This unit provides an overview of the field of synthetic peptides and proteins, including their purification. It discusses selecting the solid support and common coupling reagents. Additional information is provided regarding common side reactions and synthesizing modified residues.