UNIT 11.9A Key Molecules Involved in Receptor-Mediated Lymphocyte Activation

  1. John J. O'Shea1,
  2. James A. Johnston2,
  3. John Kehrl3,
  4. Gary Koretzky4,
  5. Lawrence E. Samelson5

Published Online: 1 NOV 2001

DOI: 10.1002/0471142735.im1109as44

Current Protocols in Immunology

Current Protocols in Immunology

How to Cite

O'Shea, J. J., Johnston, J. A., Kehrl, J., Koretzky, G. and Samelson, L. E. 2001. Key Molecules Involved in Receptor-Mediated Lymphocyte Activation. Current Protocols in Immunology. 44:11.9A:11.9A.1–11.9A.14.

Author Information

  1. 1

    National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland

  2. 2

    DNAX, Palo Alto, California

  3. 3

    National Institute of Allergy and Infectious Diseases, Bethesda, Maryland

  4. 4

    University of Iowa College of Medicine, Iowa City, Iowa

  5. 5

    National Institute of Child Health and Human Development, Bethesda, Maryland

Publication History

  1. Published Online: 1 NOV 2001
  2. Published Print: AUG 2001


This unit, along with Unit 11.9B, provides a summary of our current knowledge about various signaling pathways critical to the function of immune cells. Here, our understanding of T cell receptor (TCR)- and B cell receptor (BCR)-mediated signaling is summarized. A schematic representation of immunologically relevant cytokine receptors and the Janus Family Kinases (JAKs) that is activated through these receptors is provided, along with details about molecules involved in interleukin 2 mediated signal transduction.