UNIT 11.9D TRAF-Mediated TNFR-Family Signaling

  1. Joseph R. Arron,
  2. Matthew C. Walsh,
  3. Yongwon Choi

Published Online: 1 NOV 2002

DOI: 10.1002/0471142735.im1109ds51

Current Protocols in Immunology

Current Protocols in Immunology

How to Cite

Arron, J. R., Walsh, M. C. and Choi, Y. 2002. TRAF-Mediated TNFR-Family Signaling. Current Protocols in Immunology. 51:11.9D:11.9D.1–11.9D.14.

Author Information

  1. Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

Publication History

  1. Published Online: 1 NOV 2002
  2. Published Print: OCT 2002

This is not the most recent version of the article. View current version (1 NOV 2009)


The tumor necrosis factor (TNF) superfamily consists of a wide variety of proteins, some cell-bound and others secreted, that regulate many cellular processes. In particular, TNF-family proteins regulate the life and death not only of tumor cells, but of activated cells of the immune system. This overview discusses the six known mammalian TRAF proteins, of which TRAF1, 2, 3, 5, and 6 have been shown to interact directly or indirectly with members of the TNFR superfamily. Structural features of TRAF proteins are described along with a discussion of TRAF-interacting proteins and the signaling pathways activated by TRAF proteins. Finally, a discussion is provided on the phenotypes of TRAF-knockout mice.