UNIT 11.9D TRAF-Mediated TNFR-Family Signaling
Published Online: 1 NOV 2009
Copyright © 2009 by John Wiley & Sons, Inc.
Lab Protocol Title
Current Protocols in Immunology
How to Cite
Ha, H., Han, D. and Choi, Y. 2009. TRAF-Mediated TNFR-Family Signaling. Current Protocols in Immunology. 87:11.9D.1–11.9D.19.
- Published Online: 1 NOV 2009
- Published Print: NOV 2009
The tumor necrosis factor (TNF) superfamily consists of a wide variety of cell-bound and secreted proteins that regulate numerous cellular processes. In particular, TNF-family proteins regulate the proliferation and death of tumor cells, as well as activated immune cells. This overview discusses the mammalian TNF receptor-associated factors (TRAFs), of which TRAF1, 2, 3, 5, and 6 have been shown to interact directly or indirectly with members of the TNF receptor superfamily. Structural features of TRAF proteins are described along with a discussion of TRAF-interacting proteins and the signaling pathways activated by the TRAF proteins. Finally, we examine the phenotypes observed in TRAF-knockout mice. Curr. Protoc. Immunol. 87:11.9D.1-11.9D.19. © 2009 by John Wiley & Sons, Inc.
- TNF family;
- TNFR family;
- TRAF proteins;
- signal transduction;