UNIT 11.9D TRAF-Mediated TNFR-Family Signaling

  1. Hyunil Ha,
  2. Daehee Han,
  3. Yongwon Choi

Published Online: 1 NOV 2009

DOI: 10.1002/0471142735.im1109ds87

Current Protocols in Immunology

Current Protocols in Immunology

How to Cite

Ha, H., Han, D. and Choi, Y. 2009. TRAF-Mediated TNFR-Family Signaling. Current Protocols in Immunology. 87:11.9D:11.9D.1–11.9D.19.

Author Information

  1. University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

Publication History

  1. Published Online: 1 NOV 2009
  2. Published Print: NOV 2009


The tumor necrosis factor (TNF) superfamily consists of a wide variety of cell-bound and secreted proteins that regulate numerous cellular processes. In particular, TNF-family proteins regulate the proliferation and death of tumor cells, as well as activated immune cells. This overview discusses the mammalian TNF receptor-associated factors (TRAFs), of which TRAF1, 2, 3, 5, and 6 have been shown to interact directly or indirectly with members of the TNF receptor superfamily. Structural features of TRAF proteins are described along with a discussion of TRAF-interacting proteins and the signaling pathways activated by the TRAF proteins. Finally, we examine the phenotypes observed in TRAF-knockout mice. Curr. Protoc. Immunol. 87:11.9D.1-11.9D.19. © 2009 by John Wiley & Sons, Inc.


  • TNF family;
  • TNFR family;
  • IL-1R/TLR;
  • TRAF proteins;
  • signal transduction;
  • inflammation