UNIT 14.12 Toll-Like Receptors

  1. Kiyoshi Takeda1,
  2. Shizuo Akira2

Published Online: 1 MAY 2007

DOI: 10.1002/0471142735.im1412s77

Current Protocols in Immunology

Current Protocols in Immunology

How to Cite

Takeda, K. and Akira, S. 2007. Toll-Like Receptors. Current Protocols in Immunology. 77:14.12:14.12.1–14.12.13.

Author Information

  1. 1

    Osaka University, Osaka, Japan

  2. 2

    Osaka University and ERATO Japan Science and Technology Agency, Osaka, Japan

Publication History

  1. Published Online: 1 MAY 2007
  2. Published Print: MAY 2007


This has led to the identification of several important roles for Toll receptors in mammals. This unit discusses mammalian Toll receptors (TLR1-10) that have an essential role in the innate immune recognition of microorganisms. Also discussed are TLR-mediated signaling pathways and antibodies that are available to detect specific TLRs.


  • innate immunity;
  • Toll-like receptors;
  • NOD;
  • RNA helicase;
  • TIR domain