UNIT 15.10 Streptococcal Cell Wall Arthritis

  1. Ronald L. Wilder

Published Online: 1 MAY 2001

DOI: 10.1002/0471142735.im1510s26

Current Protocols in Immunology

Current Protocols in Immunology

How to Cite

Wilder, R. L. 2001. Streptococcal Cell Wall Arthritis. Current Protocols in Immunology. 26:15.10:15.10.1–15.10.12.

Author Information

  1. National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: JUN 1998


Streptococcal cell wall (SCW) arthritis in rats is an experimentally-induced inflammatory model with many features that resemble rheumatoid arthritis (RA) in humans. In this unit, Lewis rats are injected with an aqueous suspension of Group A SCW streptococcal cell wall peptidoglycan-polysaccharide polymers (SCW PG-PS) and observed for the development of arthritis. The resulting arthritis is biphasic. An acute phase typically develops within 48 hr, followed 10 to 21 days later by a chronic phase which persists for months. Support protocols are included for preparing Group A PG-PS and measuring PG-PS concentration.