UNIT 15.11 Animal Models of IgA Nephropathy

  1. Steven N. Emancipator

Published Online: 1 MAY 2001

DOI: 10.1002/0471142735.im1511s29

Current Protocols in Immunology

Current Protocols in Immunology

How to Cite

Emancipator, S. N. 2001. Animal Models of IgA Nephropathy. Current Protocols in Immunology. 29:15.11:15.11.1–15.11.18.

Author Information

  1. Case Western Reserve University, Cleveland, Ohio

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: FEB 1999


IgA nephropathy (IgAN) is a form of immune complex glomerulonephritis that occurs spontaneously in humans. This unit describes the induction of active disease in inbred mice, utilizing inert proteins or a common viral pathogen as the inciting antigen. An alternate protocol is offered for the induction of disease in rats by noninfectious protein antigens. Support protocols are presented for the evaluation of the extent of disease, for preparation of infectious and inactivated suspensions of viral stock, and for quantification of the virus.