UNIT 15.11 Animal Models of IgA Nephropathy
Published Online: 1 MAY 2001
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Immunology
How to Cite
Emancipator, S. N. 2001. Animal Models of IgA Nephropathy. Current Protocols in Immunology. 29:15.11:15.11.1–15.11.18.
- Published Online: 1 MAY 2001
- Published Print: FEB 1999
IgA nephropathy (IgAN) is a form of immune complex glomerulonephritis that occurs spontaneously in humans. This unit describes the induction of active disease in inbred mice, utilizing inert proteins or a common viral pathogen as the inciting antigen. An alternate protocol is offered for the induction of disease in rats by noninfectious protein antigens. Support protocols are presented for the evaluation of the extent of disease, for preparation of infectious and inactivated suspensions of viral stock, and for quantification of the virus.