UNIT 15.18 Animal Models of Airway Sensitization

  1. Eckard Hamelmann1,
  2. Erwin W. Gelfand2

Published Online: 1 MAY 2001

DOI: 10.1002/0471142735.im1518s34

Current Protocols in Immunology

Current Protocols in Immunology

How to Cite

Hamelmann, E. and Gelfand, E. W. 2001. Animal Models of Airway Sensitization. Current Protocols in Immunology. 15:15.18.

Author Information

  1. 1

    University Hospital Charité, Berlin, Germany

  2. 2

    National Jewish Medical And Research Center, Denver, Colorado

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: DEC 1999

This is not the most recent version of the article. View current version (1 NOV 2007)


Airway inflammation and hyperresponsiveness (AHR) are hallmarks and distinguishing features of bronchial asthma. This unit contains protocols that employ a mouse model for the study of allergen-induced AHR. It includes methods for sensitizing mice to allergens via the airways and assessing tracheal smooth muscle reactivity in vitro and in vivo. Protocols to measure and evaluate immunological mechanisms that contribute to the development to allergen-induced asthma are also provided.