UNIT 15.18 Animal Models of Airway Sensitization
Published Online: 1 MAY 2001
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Immunology
How to Cite
Hamelmann, E. and Gelfand, E. W. 2001. Animal Models of Airway Sensitization. Current Protocols in Immunology. 15:15.18.
- Published Online: 1 MAY 2001
- Published Print: DEC 1999
This is not the most recent version of the article. View current version (1 NOV 2007)
Airway inflammation and hyperresponsiveness (AHR) are hallmarks and distinguishing features of bronchial asthma. This unit contains protocols that employ a mouse model for the study of allergen-induced AHR. It includes methods for sensitizing mice to allergens via the airways and assessing tracheal smooth muscle reactivity in vitro and in vivo. Protocols to measure and evaluate immunological mechanisms that contribute to the development to allergen-induced asthma are also provided.