Unit

UNIT 19.4 Experimental Asexual Blood Stage Malaria Immunity

  1. Fiona H. Amante1,
  2. Christian R. Engwerda1,
  3. Michael F. Good2

Published Online: 1 APR 2011

DOI: 10.1002/0471142735.im1904s93

Current Protocols in Immunology

Current Protocols in Immunology

How to Cite

Amante, F. H., Engwerda, C. R. and Good, M. F. 2011. Experimental Asexual Blood Stage Malaria Immunity. Current Protocols in Immunology. 93:19.4:19.4.1–19.4.26.

Author Information

  1. 1

    The Queensland Institute of Medical Research, Queensland, Australia

  2. 2

    Institute for Glycomics, Gold Coast Campus, Griffith University, Queensland, Australia

Publication History

  1. Published Online: 1 APR 2011
  2. Published Print: APR 2011

Abstract

Immunity to asexual blood stages of malaria is complex, involving both humoral and cell-mediated immune mechanisms. The availability of murine models of malaria has greatly facilitated the analysis of immune mechanisms involved in resistance to the asexual blood stages. This unit details the materials and methods required for inducing protective immunity toward experimental blood stage malaria parasites by vaccination, repeated infection, and drug cure, as well as adoptive transfer of antigen-specific T cells. Curr. Protoc. Immunol. 93:19.4.1-19.4.26. © 2011 by John Wiley & Sons, Inc.

Keywords:

  • malaria;
  • Plasmodium;
  • blood stage;
  • immunity;
  • protection