UNIT 19.5 Animal Models of Mycobacteria Infection

  1. Ian M. Orme,
  2. Alan D. Roberts

Published Online: 1 MAY 2001

DOI: 10.1002/0471142735.im1905s30

Current Protocols in Immunology

Current Protocols in Immunology

How to Cite

Orme, I. M. and Roberts, A. D. 2001. Animal Models of Mycobacteria Infection. Current Protocols in Immunology. 30:19.5:19.5.1–19.5.22.

Author Information

  1. Mycobacteria Research Laboratories, Colorado State University, Fort Collins, Colorado

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: APR 1999

This is not the most recent version of the article. View current version (1 AUG 2011)


This unit describes the infection of mice and guinea pigs with mycobacteria via the aerogenic route, or of mice via the intravenous route, as well as necropsy methods for the determination of mycobacterial loads within target organs. Additionally, methods for cultivating mycobacteria and preparing stocks are described. The protocols outlined are primarily used for M. tuberculosis, but can also be used for the study of other opportunistic Mycobacterial species.