UNIT 19.10 Animal Models Using Lymphocytic Choriomeningitis Virus

  1. Matthias von Herrath,
  2. J. Lindsay Whitton

Published Online: 1 MAY 2001

DOI: 10.1002/0471142735.im1910s36

Current Protocols in Immunology

Current Protocols in Immunology

How to Cite

von Herrath, M. and Whitton, J. L. 2001. Animal Models Using Lymphocytic Choriomeningitis Virus. Current Protocols in Immunology. 36:19.10:19.10.1–19.10.19.

Author Information

  1. The Scripps Research Institute, La Jolla, California

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: APR 2000


This unit includes protocols for inducing systemic infection and persistent infection of mice with lymphocytic choriomeningitis virus (LCMV). Methods used to measure T cell responses to LCMV are then described. A protocol to assess anti-LCMV immunity in vivo is also included. Support protocols for preparing LCMV stocks and measuring LCMV titers using a plaque assay are also included. Finally, a support protocol for detecting anti-LCMV antibodies by ELISA is presented.