UNIT 19.12 Animal Model of Nippostrongylus brasiliensis and Heligmosomoides polygyrus

  1. Mali Camberis1,
  2. Graham Le Gros1,
  3. Joseph Urban Jr.2

Published Online: 1 AUG 2003

DOI: 10.1002/0471142735.im1912s55

Current Protocols in Immunology

Current Protocols in Immunology

How to Cite

Camberis, M., Le Gros, G. and Urban, J. 2003. Animal Model of Nippostrongylus brasiliensis and Heligmosomoides polygyrus. Current Protocols in Immunology. 55:19.12:19.12.1–19.12.27.

Author Information

  1. 1

    Malaghan Institute of Medical Research, Wellington, New Zealand

  2. 2

    Nutrient Requirements and Functions Laboratory, Beltsville Human Nutrition Research Center, U.S. Department of Agriculture, Beltsville, Maryland

Publication History

  1. Published Online: 1 AUG 2003
  2. Published Print: JUN 2003


Animal models of Nippostrongylus brasiliensis and Heligmosomoides polygyrus infection are powerful tools for the investigation of the basic biology of immune responses and protective immunity. In particular, they model the induction and maintenance of Th2 type immune responses and exhibit all the requisite hallmarks of CD4 T cell–dependent IgE production, eosinophilia, mastocytosis, and mucus production. This chapter describes simple, cost-effective techniques for using and maintaining these easy-to-work-with parasites in the context of a modern laboratory.


  • immunoparasitology;
  • nematodes;
  • Nippostrongylus brasiliensis;
  • Heligmosomoides polygyrus;
  • Th2 immune responses;
  • cytokines;
  • mucosal immunity;
  • allergic responses;
  • IL4;
  • IL5;
  • IL9;
  • IL13;
  • IgE;
  • eosinophils;
  • mastocytosis;
  • protective immunity;
  • worm migration;
  • parasitic diseases;
  • inflammatory responses;
  • nematode biology