Appendix

APPENDIX 1C Commonly Used Mouse Strains

  1. Ada M. Kruisbeek

Published Online: 1 MAY 2001

DOI: 10.1002/0471142735.ima01cs17

Current Protocols in Immunology

Current Protocols in Immunology

How to Cite

Kruisbeek, A. M. 2001. Commonly Used Mouse Strains. Current Protocols in Immunology. 17:1C:A.1C.1–A.1C.2.

Author Information

  1. Netherlands Cancer Institute, Amsterdam, The Netherlands

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: MAR 1996

Abstract

This appendix lists commonly used mouse strains and selected cell-surface molecules expressed by these strains. H-2 is the gene locus residing on chromosome 17 of the mouse which encodes major histocompatibility proteins. Only those H-2 loci involved in immunologic interactions frequently cited in this manual are listed here--i.e., Aa-, Ab-, Ea-, and Eb--region-encoded MHC class II molecules, and K-and D-region-encoded MHC class I molecules. In addition to H-2 loci, others are listed that encode immunologically important proteins. Congenic strains listed in this appendix represent inbred strains that were derived from their origin (BALB/c, C57Bl/10, and C3H) by selective matings, such that they differ from that originating strain at only one independently segregating genetic locus. The locus of choice in these cases was H-2; thus, these strains differ from their strain of origin only in their H-2 complex, but not in any other loci. During the production of the congenic lines, several strains were derived that had undergone intra-H-2 recombination events. These strains are listed here and have been invaluable in defining the major roles of various MHC glycoproteins.