APPENDIX 1E Murine Models of Immunodeficiency and Autoimmune Disease
Published Online: 1 MAY 2001
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Immunology
How to Cite
Cohen, P. 2001. Murine Models of Immunodeficiency and Autoimmune Disease. Current Protocols in Immunology. 17:1E:A.1E.1–A.1E.21.
- Published Online: 1 MAY 2001
- Published Print: MAR 1996
Genetically determined murine immunodeficiency states are useful for understanding the function of specific immune-system genes and cellpopulations. In addition, certain immunodeficient strains may be exploited as hosts for foreign tumors or immune cells. The more commonly used immunodeficiency models are described in this appendix. Not included are strains better known for primary neurological or neuromuscular abnormalities or for defective osteoclast function. Many of the recently described immune-deficient “knockout” strains are described, including cytokine and cytokine receptor knockout strains. The most widely studied murine strains for autoimmune disease and experimental autoreactivity are also listed.