APPENDIX 1X Paired Receptor Systems of the Innate Immune System

  1. Eriko Yamada,
  2. Daniel W. McVicar

Published Online: 1 MAY 2008

DOI: 10.1002/0471142735.ima01xs81

Current Protocols in Immunology

Current Protocols in Immunology

How to Cite

Yamada, E. and McVicar, D. W. 2008. Paired Receptor Systems of the Innate Immune System. Current Protocols in Immunology. 81:1X:A.1X.1–A.1X.25.

Author Information

  1. Cancer and Inflammation Program, Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute–Frederick, Frederick, Maryland

Publication History

  1. Published Online: 1 MAY 2008
  2. Published Print: MAY 2008


This appendix describes paired receptors involved in the innate immune system. “Paired Receptors” are defined as families of related membrane proteins that show the following characteristics: (1) they are encoded by different genes, but located as a gene cluster on a given chromosome; (2) they have significant homology within their extracellular domains; (3) they are expressed on overlapping immune populations; and (4) they are confirmed to have both activating and inhibitory members. For simplicity in nomenclature, the authors used the official gene nomenclature provided by NCBI and listed all other names in the alias field. Paired receptor information related to both mouse and human systems is included, as some families exist in both species whereas others are important in the study of either human or murine models of disease. Curr. Protoc. Immunol. 81:A.1X.1-A.1X.25. © 2008 by John Wiley & Sons, Inc.


  • immune regulation;
  • adaptive immunity;
  • cell signaling