Unit

UNIT 1.2 Pedigree Selection and Information Content

  1. Elizabeth R. Hauser (revision)1,
  2. Daniel E. Weeks (original author)2

Published Online: 1 AUG 2001

DOI: 10.1002/0471142905.hg0102s29

Current Protocols in Human Genetics

Current Protocols in Human Genetics

How to Cite

Hauser, E. R. and Weeks, D. E. 2001. Pedigree Selection and Information Content. Current Protocols in Human Genetics. 29:1.2:1.2.1–1.2.22.

Author Information

  1. 1

    Duke University Medical Center, Durham, North Carolina

  2. 2

    University of Pittsburgh, Pittsburgh, Pennsylvania

Publication History

  1. Published Online: 1 AUG 2001
  2. Published Print: MAY 2001

Abstract

This unit covers the important criteria and methods for appropriately selecting pedigrees for linkage analysis. It includes methods for determining the power of a dataset to detect genetic loci for both model-based (lod score) and model-free (affected sib-pair, affected-relative pair) analyses.This unit covers the important criteria and methods for appropriately selecting pedigrees for linkage analysis.