UNIT 1.5 Construction of Reference Genetic Maps

  1. Kenneth H. Buetow

Published Online: 1 MAY 2001

DOI: 10.1002/0471142905.hg0105s01

Current Protocols in Human Genetics

Current Protocols in Human Genetics

How to Cite

Buetow, K. H. 2001. Construction of Reference Genetic Maps. Current Protocols in Human Genetics. 1:1.5:1.5.1–1.5.8.

Author Information

  1. Fox Chase Cancer Center, Philadelphia, Pennsylvania

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: MAY 1994


This unit details the specialized resources and procedures used for constructing reference genetic maps. Construction of such maps in humans represents a subset of the linkage analysis problem. Objectives include the addition of a new locus to an established map, development of a detailed map of loci in a localized area, and construction of de novo maps. Conceptually, the procedures for updating a reference map through the addition of a subset of new loci are similar to those used in establishing linkage for a disease locus. However, construction of new maps of multiple loci is most efficiently accomplished using different family resources that permit the use of accumulated typing resources and alternative, highly efficient statistical methods.