UNIT 1.8 Model-Free Tests for Genetic Linkage

  1. Christopher I. Amos1,
  2. Audrey Schnell2,
  3. Wei V. Chen1,
  4. Robert C. Elston3

Published Online: 1 OCT 2012

DOI: 10.1002/0471142905.hg0108s75

Current Protocols in Human Genetics

Current Protocols in Human Genetics

How to Cite

Amos, C. I., Schnell, A., Chen, W. V. and Elston, R. C. 2012. Model-Free Tests for Genetic Linkage. Current Protocols in Human Genetics. 75:1.8:1.8.1–1.8.32.

Author Information

  1. 1

    University of Texas, M.D. Anderson Cancer Center, Houston, Texas

  2. 2

    University of Washington, Seattle, Washington

  3. 3

    Case Western University, Cleveland, Ohio

Publication History

  1. Published Online: 1 OCT 2012


This unit covers statistical methods of linkage analysis that do not require the assumption of a detailed genetic model, as is required for standard lod score analysis. The unit has been updated to include the latest methods in sib-pair analysis, including updates to using the software program SIBPAL as well as the relative-pair analysis software applications GENEHUNTER, GENEHUNTER PLUS, and Merlin. Curr. Protoc. Hum. Genet. 75:1.8.1-1.8.32. © 2012 by John Wiley & Sons, Inc.


  • robust linkage tests;
  • pedigree methods;
  • sib pair tests