UNIT 1.8 Model-Free Tests for Genetic Linkage
Published Online: 1 OCT 2012
Copyright © 2012 by John Wiley & Sons, Inc.
Lab Protocol Title
Current Protocols in Human Genetics
How to Cite
Amos, C. I., Schnell, A., Chen, W. V. and Elston, R. C. 2012. Model-Free Tests for Genetic Linkage. Current Protocols in Human Genetics. 75:1.8:1.8.1–1.8.32.
- Published Online: 1 OCT 2012
This unit covers statistical methods of linkage analysis that do not require the assumption of a detailed genetic model, as is required for standard lod score analysis. The unit has been updated to include the latest methods in sib-pair analysis, including updates to using the software program SIBPAL as well as the relative-pair analysis software applications GENEHUNTER, GENEHUNTER PLUS, and Merlin. Curr. Protoc. Hum. Genet. 75:1.8.1-1.8.32. © 2012 by John Wiley & Sons, Inc.
- robust linkage tests;
- pedigree methods;
- sib pair tests