UNIT 1.14 Analysis of Gene-Gene Interactions

  1. Diane Gilbert-Diamond1,
  2. Jason H. Moore1,2,3,4

Published Online: 1 JUL 2011

DOI: 10.1002/0471142905.hg0114s70

Current Protocols in Human Genetics

Current Protocols in Human Genetics

How to Cite

Gilbert-Diamond, D. and Moore, J. H. 2011. Analysis of Gene-Gene Interactions. Current Protocols in Human Genetics. 70:1.14:1.14.1–1.14.12.

Author Information

  1. 1

    Computational Genetics Laboratory, Departments of Genetics and Community and Family Medicine, Dartmouth Medical School, Lebanon, New Hampshire

  2. 2

    Department of Computer Science, University of New Hampshire, Durham, New Hampshire

  3. 3

    Department of Computer Science, University of Vermont, Burlington, Vermont

  4. 4

    Institute for Quantitative Biomedical Sciences, Dartmouth College, Hanover, New Hampshire

Publication History

  1. Published Online: 1 JUL 2011
  2. Published Print: JUL 2011


The goal of this unit is to introduce gene-gene interactions (epistasis) as a significant complicating factor in the search for disease susceptibility genes. This unit begins with an overview of gene-gene interactions and why they are likely to be common. Then, it reviews several statistical and computational methods for detecting and characterizing genes with effects that are dependent on other genes. The focus of this unit is genetic association studies of discrete and quantitative traits because most of the methods for detecting gene-gene interactions have been developed specifically for these study designs. Curr. Protoc. Hum. Genet. 70:1.14.1-1.14.12 © 2011 by John Wiley & Sons, Inc.


  • epistasis;
  • genetics;
  • statistics;
  • bioinformatics