UNIT 1.14 Analysis of Gene-Gene Interactions
Published Online: 1 JUL 2011
Copyright © 2011 by John Wiley & Sons, Inc.
Lab Protocol Title
Current Protocols in Human Genetics
How to Cite
Gilbert-Diamond, D. and Moore, J. H. 2011. Analysis of Gene-Gene Interactions. Current Protocols in Human Genetics. 70:1.14:1.14.1–1.14.12.
- Published Online: 1 JUL 2011
- Published Print: JUL 2011
The goal of this unit is to introduce gene-gene interactions (epistasis) as a significant complicating factor in the search for disease susceptibility genes. This unit begins with an overview of gene-gene interactions and why they are likely to be common. Then, it reviews several statistical and computational methods for detecting and characterizing genes with effects that are dependent on other genes. The focus of this unit is genetic association studies of discrete and quantitative traits because most of the methods for detecting gene-gene interactions have been developed specifically for these study designs. Curr. Protoc. Hum. Genet. 70:1.14.1-1.14.12 © 2011 by John Wiley & Sons, Inc.