Unit

UNIT 1.21 Using the PhenX Toolkit to Add Standard Measures to a Study

  1. Tabitha Hendershot1,
  2. Huaqin Pan1,
  3. Jonathan Haines2,
  4. William R. Harlan3,
  5. Heather A. Junkins4,
  6. Erin M. Ramos4,
  7. Carol M. Hamilton1

Published Online: 1 OCT 2011

DOI: 10.1002/0471142905.hg0121s71

Current Protocols in Human Genetics

Current Protocols in Human Genetics

How to Cite

Hendershot, T., Pan, H., Haines, J., Harlan, W. R., Junkins, H. A., Ramos, E. M. and Hamilton, C. M. 2011. Using the PhenX Toolkit to Add Standard Measures to a Study. Current Protocols in Human Genetics. 71:1.21:1.21.1–1.21.18.

Author Information

  1. 1

    RTI International, Research Triangle Park, North Carolina

  2. 2

    Center for Human Ethics Research, Vanderbilt University, Nashville, Tennessee

  3. 3

    Retired, Associate Director for Disease Prevention, Office of the Director, National Institutes of Health, Bethesda, Maryland

  4. 4

    Office of Population Genomics, National Human Genome Research Institute, Bethesda, Maryland

Publication History

  1. Published Online: 1 OCT 2011
  2. Published Print: OCT 2011

Abstract

The PhenX (consensus measures for Phenotypes and eXposures) Toolkit (https://www.phenxtoolkit.org/) offers high-quality, well-established measures of phenotypes and exposures for use by the scientific community. The Toolkit contains 295 measures drawn from 21 research domains (fields of research). The measures were selected by Working Groups of domain experts using a consensus process that included input from the scientific community. The Toolkit provides a description of each PhenX measure, the rationale for including it in the Toolkit, protocol(s) for collecting the measure, and supporting documentation. Users can browse by measures, domains, or collections, or can search the Toolkit using the Smart Query Tool. Once users have selected some measures, they can download a customized Data Collection Worksheet that specifies what information needs to be collected, and a Data Dictionary that describes each variable included in their Data Collection Worksheet. To help researchers find studies with comparable data, PhenX measures and variables are being mapped to studies in the database of Genotypes and Phenotypes (dbGaP). Curr. Protoc. Hum. Genet. 71:1.21.1-1.21.18 © 2011 by John Wiley & Sons, Inc.

Keywords:

  • genome-wide association studies (GWAS);
  • PhenX (consensus measures for Phenotypes and eXposures);
  • phenotypes;
  • environmental exposures