UNIT 1.24 Methods for Meta-Analysis of Genetic Data
Published Online: 1 APR 2013
Copyright © 2013 by John Wiley & Sons, Inc.
Lab Protocol Title
Current Protocols in Human Genetics
How to Cite
Lunetta, K. L. 2013. Methods for Meta-Analysis of Genetic Data. Current Protocols in Human Genetics. 77:1.24:1.24.1–1.24.8.
- Published Online: 1 APR 2013
Modern genetic association studies, using genome-wide genotype data, are often underpowered. Meta-analyses of multiple studies performing genome-wide genotyping improve power and have led to the identification of thousands of genotype-trait associations. This unit provides an overview of the key concepts required for genetic meta-analyses, and presents strategic approaches and key decisions that must be made in the process of performing genome-wide association study (GWAS) meta-analyses. The commentary discusses the interpretation of GWAS meta-analysis results, complications, and some of the possible next steps once a GWAS meta-analysis has successfully identified regions associated with a trait. Curr. Protoc. Hum. Genet. 77:1.24.1-1.24.8. © 2013 by John Wiley & Sons, Inc.
- genome-wide association;
- genetic association analysis;
- common variants