UNIT 4.8 Chromosome Microdissection

  1. Paul Meltzer,
  2. Michael Bittner

Published Online: 1 MAY 2001

DOI: 10.1002/0471142905.hg0408s14

Current Protocols in Human Genetics

Current Protocols in Human Genetics

How to Cite

Meltzer, P. and Bittner, M. 2001. Chromosome Microdissection. Current Protocols in Human Genetics. 14:4.8:4.8.1–4.8.17.

Author Information

  1. National Institute for Human Genome Research, Bethesda, Maryland

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: AUG 1997


This unit describes chromosome microdissection methodologies that are useful in both clinical and research laboratories. In combination with FISH, region-specific probes can be made to determine the origin of marker chromosomes. Another application of the microdissection technology is in the generation of regionspecific cDNA libraries, known as microdissection-mediated cDNA capture.