UNIT 10.1 Overview of Genetic Diagnosis in Cancer
Published Online: 1 OCT 2007
Copyright © 2007 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Human Genetics
How to Cite
Korf, B. and M. Mikhail, F. 2007. Overview of Genetic Diagnosis in Cancer. Current Protocols in Human Genetics. 55:10.1:10.1.1–10.1.8.
- Published Online: 1 OCT 2007
- Published Print: OCT 2007
Both cytogenetic and molecular genetic studies can contribute to the management of patients with cancer. In some cases genetic markers are specific to particular tumor types and are useful in diagnosis. This can be helpful in distinguishing histologically similar tumors that may respond differently to treatment and can sometimes be of prognostic value. Genetic markers can also be tools for following the response of a tumor to therapy, providing a sensitive means of detection of relapse. This introductory unit considers some of the types of genetic changes that occur in association with malignancies and major approaches used in their detection. Curr. Protoc. Hum. Genet. 55:10.1.1-10.1.8. © 2007 by John Wiley & Sons, Inc.
- tumor suppressor gene;