Unit

UNIT 12.8 Liposome Vectors for In Vivo Gene Delivery

  1. Mark Whitemore,
  2. Song Li,
  3. Leaf Huang

Published Online: 1 MAY 2001

DOI: 10.1002/0471142905.hg1208s20

Current Protocols in Human Genetics

Current Protocols in Human Genetics

How to Cite

Whitemore, M., Li, S. and Huang, L. 2001. Liposome Vectors for In Vivo Gene Delivery. Current Protocols in Human Genetics. 20:12.8:12.8.1–12.8.9.

Author Information

  1. University of Pittsburgh, Pittsburgh, Pennsylvanta

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: FEB 1999

Abstract

Gene therapy with nonviral, cationic liposomebased vectors has demonstrated promising results in a variety of in vivo models and some clinical trials. In contrast to viral vectors, cationic liposomebased vectors usually induce just mild inflammatory reactions, making them suitable for repeated injections in animals. This unit describes the preparation and delivery of two liposomebased vectorsGene therapy with nonviral, cationic liposomebased vectors has demonstrated promising results in a variety of in vivo models.