UNIT 9.16 Signal Transduction During Natural Killer Cell Activation

  1. Claudia C.S. Chini,
  2. Paul J. Leibson

Published Online: 1 MAY 2001

DOI: 10.1002/0471142956.cy0916s14

Current Protocols in Cytometry

Current Protocols in Cytometry

How to Cite

Chini, C. C. and Leibson, P. J. 2001. Signal Transduction During Natural Killer Cell Activation. Current Protocols in Cytometry. 14:9.16:9.16.1–9.16.13.

Author Information

  1. Mayo Clinic and Foundation, Rochester, Minnesota

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: OCT 2000


Understanding of transmembrane signaling during NK-cell activation has greatly expanded during the past few years. The discovery and characterization of novel triggering and inhibitory receptors have revealed the complexity of these processes. This unit focuses on receptor-initiated signaling pathways that modulate NK functions. Establishing the roles of different signaling pathways in NK cells is a crucial step in the design of therapeutic approaches for selective enhancement or suppression of NK-cell activation.