UNIT 8.1 Overview of the Cell Cycle

  1. Michele S. Park,
  2. Andrew Koff

Published Online: 1 MAY 2001

DOI: 10.1002/0471143030.cb0801s00

Current Protocols in Cell Biology

Current Protocols in Cell Biology

How to Cite

Park, M. S. and Koff, A. 2001. Overview of the Cell Cycle. Current Protocols in Cell Biology. 00:8.1:8.1.1–8.1.9.

Author Information

  1. Memorial Sloan-Kettering Cancer Center, New York, New York

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: OCT 1998


Progression through the cell cycle is regulated by inductive signals from outside the cell and intracellular signal pathways, while the cycle itself is regulated by cyclin-dependent kinases (CDKs). An understanding of the functions of these molecules is necessary to understand the processes of mitosis, differentiation, senescence, apoptosis, and tumorigenesis. This overview reviews the current state of knowledge for the biology of the cell-cycle, the CDKs, the role of proteolysis, targets of the cell cycle machinery, and a paradigm of cell cycle analysis.