UNIT 19.5 The Chick Chorioallantoic Membrane as an In Vivo Angiogenesis Model
Published Online: 1 MAY 2003
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Cell Biology
How to Cite
Ponce, M. L. and Kleinmann, H. K. 2003. The Chick Chorioallantoic Membrane as an In Vivo Angiogenesis Model. Current Protocols in Cell Biology. 18:19.5:19.5.1–19.5.6.
- Published Online: 1 MAY 2003
- Published Print: MAR 2003
The chick chorioallantoic membrane (CAM) assay for angiogenic activity is a model originally developed to study the angiogenic activity of tumor samples. It is an in vivo assay that can be readily performed in any laboratory setting. The effects of a test compound on angiogenesis are tested by exposing day 10 embryos to the compound and following the patterns of blood vessel development, scoring the appearance of the CAM at day 12 or 13.