Unit

UNIT 19.5 The Chick Chorioallantoic Membrane as an In Vivo Angiogenesis Model

  1. M. Lourdes Ponce,
  2. Hynda K. Kleinmann

Published Online: 1 MAY 2003

DOI: 10.1002/0471143030.cb1905s18

Current Protocols in Cell Biology

Current Protocols in Cell Biology

How to Cite

Ponce, M. L. and Kleinmann, H. K. 2003. The Chick Chorioallantoic Membrane as an In Vivo Angiogenesis Model. Current Protocols in Cell Biology. 18:19.5:19.5.1–19.5.6.

Author Information

  1. National Institutes of Health Bethesda, Maryland

Publication History

  1. Published Online: 1 MAY 2003
  2. Published Print: MAR 2003

Abstract

The chick chorioallantoic membrane (CAM) assay for angiogenic activity is a model originally developed to study the angiogenic activity of tumor samples. It is an in vivo assay that can be readily performed in any laboratory setting. The effects of a test compound on angiogenesis are tested by exposing day 10 embryos to the compound and following the patterns of blood vessel development, scoring the appearance of the CAM at day 12 or 13.