6. LC/MS Applications

  1. Mike S. Lee

Published Online: 27 JUN 2003

DOI: 10.1002/0471218812.ch6

LC/MS Applications in Drug Development

LC/MS Applications in Drug Development

How to Cite

Lee, M. S. (2002) LC/MS Applications, in LC/MS Applications in Drug Development, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471218812.ch6

Publication History

  1. Published Online: 27 JUN 2003
  2. Published Print: 20 FEB 2002

Book Series:

  1. Wiley-Interscience Series on Mass Spectrometry

Book Series Editors:

  1. Dominic M. Desiderio1 and
  2. Nico M. M. Nibbering2

Series Editor Information

  1. 1

    Departments of Neurology and Biochemistry, University of Tennessee Health Science Center, USA

  2. 2

    University of Amsterdam, USA

ISBN Information

Print ISBN: 9780471405207

Online ISBN: 9780471218814

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Keywords:

  • LC/MS applications;
  • drug discovery;
  • glycoprotein mapping;
  • natural products dereplication;
  • open-access LC/MS;
  • in vivo drug screening;
  • in vitro drug screening;
  • preclinical development;
  • clinical development;
  • manufacturing

Summary

The LC/MS applications in this Chapter are organized into the respective drug development stages: drug discovery, preclinical development, clinical development, and manufacturing. A sequential illustration of pharmaceutical analysis activities provides a unique perspective on the contributions of LC/MS techniques in drug development. The specific selected examples help to illustrate the successful incorporation of LC/MS-based analysis strategies in the pharmaceutical industry and to highlight their impact on accelerated drug development.