Chapter 7. Cytogenetics and Pseudogenetics
Published Online: 20 JUN 2002
DOI: 10.1002/0471220566.ch7
Copyright © 1999 John Wiley & Sons, Inc.
Book Title
Genomics: The Science and Technology Behind the Human Genome Project
Additional Information
How to Cite
Cantor, C. R. and Smith, C. L. (2002) Cytogenetics and Pseudogenetics, in Genomics: The Science and Technology Behind the Human Genome Project, John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471220566.ch7
Publication History
- Published Online: 20 JUN 2002
- Published Print: 2 FEB 1999
ISBN Information
Print ISBN: 9780471599081
Online ISBN: 9780471220565
- Summary
- Chapter
Keywords:
- cytogenetics;
- pseudogenetics;
- somatic cell genetics;
- subchromosomal mapping panels;
- radiation hybrids;
- single-sperm PCR;
- in situ hybridization;
- high-resolution FISH;
- chromosome painting;
- chromosome microdissection
Summary
Frequently one already has a DNA marker believed to be of interest in the search for a particular gene, or just of interest as a potential tool for higher-resolution genome mapping. In such cases it is almost always useful to pinpoint the approximate location of this marker within the genome as rapidly and efficiently as possible. As discussed in this chapter, this is the realm of cytogenetic and pseudogenetic methods.