Chapter 8. Physical Mapping

  1. Charles R. Cantor,
  2. Cassandra L. Smith

Published Online: 20 JUN 2002

DOI: 10.1002/0471220566.ch8

Book Title

Genomics: The Science and Technology Behind the Human Genome Project

Genomics: The Science and Technology Behind the Human Genome Project

Additional Information

How to Cite

Cantor, C. R. and Smith, C. L. (2002) Physical Mapping, in Genomics: The Science and Technology Behind the Human Genome Project, John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471220566.ch8

Author Information

  1. Center for Advanced Biotechnology, Boston University, Boston, Massachusetts

Publication History

  1. Published Online: 20 JUN 2002
  2. Published Print: 2 FEB 1999

ISBN Information

Print ISBN: 9780471599081

Online ISBN: 9780471220565

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CHAPTER TOOLS

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Keywords:

  • physical maps;
  • restriction maps;
  • ordered libraries;
  • restriction nuclease genomic digests;
  • HTF islands;
  • restriction fragments;
  • rare-cutting restriction enzyme;
  • fragment lengths;
  • linking clones;
  • jumping libraries;
  • partial digestion;
  • DNA polymorphism;
  • telomeres;
  • optical mapping

Summary

There are basically two kinds of physical maps commonly used in genome studies: restriction maps and ordered clone banks or ordered libraries. The authors discuss the basic methodologies used in both approaches. First they outline the relative advantages and disadvantages of each type of map.

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