Chapter 9. Enhanced Methods for Physical Mapping
Published Online: 20 JUN 2002
DOI: 10.1002/0471220566.ch9
Copyright © 1999 John Wiley & Sons, Inc.
Book Title
Genomics: The Science and Technology Behind the Human Genome Project
Additional Information
How to Cite
Cantor, C. R. and Smith, C. L. (2002) Enhanced Methods for Physical Mapping, in Genomics: The Science and Technology Behind the Human Genome Project, John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471220566.ch9
Publication History
- Published Online: 20 JUN 2002
- Published Print: 2 FEB 1999
ISBN Information
Print ISBN: 9780471599081
Online ISBN: 9780471220565
- Summary
- Chapter
Keywords:
- physical mapping;
- mapping methods;
- yeast artificial chromosomes (YACs);
- vector obsolescence;
- hybrid mapping;
- sequence-specific tags;
- simple pooling schemes;
- false positives;
- general pooling schemes;
- alternate array configurations;
- inner product mapping;
- sliced PFG fractionations;
- restriction landmark;
- genome scanning
Summary
It would be especially desirable if methods could eventually be developed that focus directly on map differences between individuals or species. Many future studies will doubtlessly be interested only in differences between two otherwise fairly homologous samples. Today techniques for effective differential mapping are unknown, and the authors largely focus instead on methods for making direct mapping approaches much more efficient.