Chapter 10. Genomic Imprinting in the Mouse

  1. Eric Engel,
  2. Stylianos E. Antonarakis
  1. Robert Lyle Ph.D.

Published Online: 19 MAR 2002

DOI: 10.1002/0471221937.ch10

Book Title

Genomic Imprinting and Uniparental Disomy in Medicine: Clinical and Molecular Aspects

Genomic Imprinting and Uniparental Disomy in Medicine: Clinical and Molecular Aspects

Additional Information

How to Cite

Engel, E. and Antonarakis, S. E. (2002) Genomic Imprinting in the Mouse, in Genomic Imprinting and Uniparental Disomy in Medicine: Clinical and Molecular Aspects, John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471221937.ch10

Author Information

  1. Division of Medical Genetics, University of Geneva Medical School

Author Information

  1. Division of Medical Genetics, University of Geneva Medical School

Publication History

  1. Published Online: 19 MAR 2002
  2. Published Print: 15 OCT 2001

ISBN Information

Print ISBN: 9780471351269

Online ISBN: 9780471221937

SEARCH

CHAPTER TOOLS

Get PDF (571K)

Keywords:

  • mouse models;
  • imprinted genes;
  • imprint;
  • gametogenesis;
  • imprinting mechanism;
  • methylation;
  • Prader-Willi syndrome

Summary

From early manipulations of mouse embryos to present-day manipulations of DNA, the mouse has provided an excellent model to study both the mechanisms of imprinting and UPD in human disease. This chapter reviews the work in mice which led to the identification of imprinted genes. It also highlights how our understanding of imprinting has come from data on both mouse and human, and shows how the mouse can be used to model human imprinting disorders.

Get PDF (571K)