Chapter 3. Mechanisms Generating Uniparental Disomy and Genomic Imprinting Disorders

  1. Eric Engel,
  2. Stylianos E. Antonarakis

Published Online: 19 MAR 2002

DOI: 10.1002/0471221937.ch3

Book Title

Genomic Imprinting and Uniparental Disomy in Medicine: Clinical and Molecular Aspects

Genomic Imprinting and Uniparental Disomy in Medicine: Clinical and Molecular Aspects

Additional Information

How to Cite

Engel, E. and Antonarakis, S. E. (2002) Mechanisms Generating Uniparental Disomy and Genomic Imprinting Disorders, in Genomic Imprinting and Uniparental Disomy in Medicine: Clinical and Molecular Aspects, John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471221937.ch3

Author Information

  1. Division of Medical Genetics, University of Geneva Medical School

Publication History

  1. Published Online: 19 MAR 2002
  2. Published Print: 15 OCT 2001

ISBN Information

Print ISBN: 9780471351269

Online ISBN: 9780471221937

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Keywords:

  • trisomy rescue;
  • monosomy rescue;
  • gamete complementation;
  • chromosomal translocation;
  • acrocentric chromosomes;
  • recombination;
  • chromosomal misdivision;
  • meiosis;
  • mitosis;
  • mosaicism

Summary

This chapter details the mechanisms and types of chromosomal events that result in UPD; trisomy rescue, monosomy rescue, gamete complementation, chromosomal translocation, and other chromosomal abnormalities. Most of these mechanisms involve two distinct errors which could be both meiotic, or meiotic and mitotic.

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