Chapter 1. The Role of GATA-1 and FOG in Erythroid and Megakaryocytic Differentiation

  1. Katya Ravid2,
  2. Jonathan D. Licht3
  1. Alice P. Tsang,
  2. John D. Crispino,
  3. Stuart H. Orkin

Published Online: 19 MAR 2002

DOI: 10.1002/0471223883.ch1

Book Title

Transcription Factors: Normal and Malignant Development of Blood Cells

Transcription Factors: Normal and Malignant Development of Blood Cells

Additional Information

How to Cite

Tsang, A. P., Crispino, J. D. and Orkin, S. H. (2002) The Role of GATA-1 and FOG in Erythroid and Megakaryocytic Differentiation, in Transcription Factors: Normal and Malignant Development of Blood Cells (eds K. Ravid and J. D. Licht), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223883.ch1

Editor Information

  1. 2

    Department of Biochemistry, Boston University School of Medicine, Boston, MA

  2. 3

    Derald H. Ruttenberg Cancer Center and Department of Medicine, Mount Sinai School of Medicine, New York, NY

Author Information

  1. Children's Hospital, Enders Research Building, Room 761, 300 Longwood Avenue, Boston, MA 02115

Publication History

  1. Published Online: 19 MAR 2002
  2. Published Print: 15 DEC 2000

ISBN Information

Print ISBN: 9780471350545

Online ISBN: 9780471223887

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Keywords:

  • GATA-1;
  • friend of GATA-1 (FOG);
  • erythroid differentiation;
  • megakaryocyte differentiation;
  • terminal erythroid maturation;
  • megakaryocyte development;
  • erythroid development;
  • GATA-1:FOG complex;
  • erythroid gene expression

Summary

Several lines of evidence suggest that FOG is an essential cofactor for GATA-1 in hematopoiesis. First, FOG is coexpressed with GATA-1 during embryonic development and within erythroid cells and megakaryocytes. Second, FOG cooperates with GATA-1 in promoting both erythroid and megakaryocytic maturation in cellular assays. Third, both FOG and GATA-1 are required for terminal erythroid differentiation in vivo. Finally, the physical interaction between FOG and GATA-1 is necessary for the differentiation activity of GATA-1 in erythroid cells.

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