Chapter 10. The Role of Retinoic Acid Receptors in Myeloid Differentiation
- Katya Ravid2,
- Jonathan D. Licht3
Published Online: 19 MAR 2002
DOI: 10.1002/0471223883.ch10
Copyright © 2001 by Wiley-Liss, Inc.
Book Title
Transcription Factors: Normal and Malignant Development of Blood Cells
Additional Information
How to Cite
Collins, S. J., Johnson, B. S. and Purton, L. E. (2002) The Role of Retinoic Acid Receptors in Myeloid Differentiation, in Transcription Factors: Normal and Malignant Development of Blood Cells (eds K. Ravid and J. D. Licht), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223883.ch10
Editor Information
- 2
Department of Biochemistry, Boston University School of Medicine, Boston, MA
- 3
Derald H. Ruttenberg Cancer Center and Department of Medicine, Mount Sinai School of Medicine, New York, NY
Publication History
- Published Online: 19 MAR 2002
- Published Print: 15 DEC 2000
ISBN Information
Print ISBN: 9780471350545
Online ISBN: 9780471223887
- Summary
- Chapter
Keywords:
- retinoic acid (RA) receptors;
- acute promyelocytic leukemia (APL);
- fusion transcript;
- hematopoietic lineage-specific activation;
- early myeloid precursors
Summary
In this chapter the authors focus on the role that retinoic acid receptors play in regulating myeloid differentiation. They address the central paradox of why the human leukemia cells that are the most sensitive to retinoic acid (i.e, APL) are those that harbor an aberrant retinoic acid receptor. They discuss some experimental evidence indicating differences in activity of RARa in different hematopoietic lineages. They also present some recent experimental observations indicating that ATRA, while being a potent inducer of promyelocyte differentiation, may enhance the self-renewal and actually prevent or delay the differentiation of more primitive hematopoietic precursors.