Chapter 11. Transcriptional Targets of the Vitamin D3 Receptor During Myeloid Cell Differentiation

  1. Katya Ravid2,
  2. Jonathan D. Licht3
  1. V. Carrie Bromleigh,
  2. Jeremy Ward,
  3. Leonard P. Freedman

Published Online: 19 MAR 2002

DOI: 10.1002/0471223883.ch11

Book Title

Transcription Factors: Normal and Malignant Development of Blood Cells

Transcription Factors: Normal and Malignant Development of Blood Cells

Additional Information

How to Cite

Bromleigh, V. C., Ward, J. and Freedman, L. P. (2002) Transcriptional Targets of the Vitamin D3 Receptor During Myeloid Cell Differentiation, in Transcription Factors: Normal and Malignant Development of Blood Cells (eds K. Ravid and J. D. Licht), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223883.ch11

Editor Information

  1. 2

    Department of Biochemistry, Boston University School of Medicine, Boston, MA

  2. 3

    Derald H. Ruttenberg Cancer Center and Department of Medicine, Mount Sinai School of Medicine, New York, NY

Author Information

  1. Memorial Sloan Kettering Cancer Center, Cell Biology Program, 1275 York Avenue, New York, NY 10021

Publication History

  1. Published Online: 19 MAR 2002
  2. Published Print: 15 DEC 2000

ISBN Information

Print ISBN: 9780471350545

Online ISBN: 9780471223887

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Keywords:

  • vitamin D3 receptor (VDR);
  • transcriptional targets;
  • myeloid cell differentiation;
  • monocytic differentiation;
  • acute promyelocytic leukemia (APL)

Summary

The emergence of 1,25(OH)2D3 as a general inhibitor of cell proliferation and inducer of myeloid differentiation has renewed interest in this ligand as a potentially efficacious chemotherapeutic for several types of cancers, including leukemias, and solid tumors such as breast and prostate. This relatively new biology of vitamin D has also stimulated interest in the development of synthetic vitamin D compounds for a variety of clinical applications, especially cancer.

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