Chapter 12. The Role of Ikaros Family Genes in Lymphocyte Differentiation and Proliferation
- Katya Ravid2,
- Jonathan D. Licht3
Published Online: 19 MAR 2002
DOI: 10.1002/0471223883.ch12
Copyright © 2001 by Wiley-Liss, Inc.
Book Title
Transcription Factors: Normal and Malignant Development of Blood Cells
Additional Information
How to Cite
Avitahl, N., Winandy, S. and Georgopoulos, K. (2002) The Role of Ikaros Family Genes in Lymphocyte Differentiation and Proliferation, in Transcription Factors: Normal and Malignant Development of Blood Cells (eds K. Ravid and J. D. Licht), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223883.ch12
Editor Information
- 2
Department of Biochemistry, Boston University School of Medicine, Boston, MA
- 3
Derald H. Ruttenberg Cancer Center and Department of Medicine, Mount Sinai School of Medicine, New York, NY
Publication History
- Published Online: 19 MAR 2002
- Published Print: 15 DEC 2000
ISBN Information
Print ISBN: 9780471350545
Online ISBN: 9780471223887
- Summary
- Chapter
Keywords:
- Ikaros family proteins;
- gene expression;
- Aiolos genes;
- lymphocyte development;
- lymphocyte homeostasis;
- lymphocyte proliferation
Summary
Ikaros, aided by Aiolos, appears to play a central role in B and T cells to integrate signals received from the cell surface to events regulating transcription, cell cycle progression, and DNA replication. The authors propose that Ikaros family proteins might nucleate the formation of different complexes in various cell types corresponding either to different lineages or developmental stages.