Chapter 13. The Role of PU.1 in B-lymphocyte Development and Function

  1. Katya Ravid3,
  2. Jonathan D. Licht4
  1. Sridhar Rao1,
  2. M. Celeste Simon2

Published Online: 19 MAR 2002

DOI: 10.1002/0471223883.ch13

Book Title

Transcription Factors: Normal and Malignant Development of Blood Cells

Transcription Factors: Normal and Malignant Development of Blood Cells

Additional Information

How to Cite

Rao, S. and Simon, M. C. (2002) The Role of PU.1 in B-lymphocyte Development and Function, in Transcription Factors: Normal and Malignant Development of Blood Cells (eds K. Ravid and J. D. Licht), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223883.ch13

Editor Information

  1. 3

    Department of Biochemistry, Boston University School of Medicine, Boston, MA

  2. 4

    Derald H. Ruttenberg Cancer Center and Department of Medicine, Mount Sinai School of Medicine, New York, NY

Author Information

  1. 1

    Department of Pathology, The University of Chicago, Chicago, IL

  2. 2

    University of Chicago, Howard Hughes Medical Institute, MC 1028, 5841 South Maryland Avenue, Chicago, IL 60637

Publication History

  1. Published Online: 19 MAR 2002
  2. Published Print: 15 DEC 2000

ISBN Information

Print ISBN: 9780471350545

Online ISBN: 9780471223887

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CHAPTER TOOLS

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Keywords:

  • PU.1, B-lymphocytes;
  • PU.1/Spi-1 expression;
  • structure-function relationships;
  • protein:protein interactions;
  • PU.1:PIP interactions;
  • ternary complex formation;
  • gene regulation;
  • B-cell-specific PU.1 target genes;
  • Spi-B;
  • genetic models

Summary

This review focuses on PU.1 function in B cells and studies used to elucidate its role in transcriptional regulation. In addition, Spi-B and Pip are each discussed to illustrate how (1) members of a gene family and (2) protein:protein interactions can influence transcription.

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