Chapter 14. The Role of Pax5 (BSAP) in Early and Late B-Cell Development

  1. Katya Ravid2,
  2. Jonathan D. Licht3
  1. Markus Horcher,
  2. Dirk Eberhard,
  3. Meinrad Busslinger

Published Online: 19 MAR 2002

DOI: 10.1002/0471223883.ch14

Book Title

Transcription Factors: Normal and Malignant Development of Blood Cells

Transcription Factors: Normal and Malignant Development of Blood Cells

Additional Information

How to Cite

Horcher, M., Eberhard, D. and Busslinger, M. (2002) The Role of Pax5 (BSAP) in Early and Late B-Cell Development, in Transcription Factors: Normal and Malignant Development of Blood Cells (eds K. Ravid and J. D. Licht), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223883.ch14

Editor Information

  1. 2

    Department of Biochemistry, Boston University School of Medicine, Boston, MA

  2. 3

    Derald H. Ruttenberg Cancer Center and Department of Medicine, Mount Sinai School of Medicine, New York, NY

Author Information

  1. Research Institute of Molecular Pathology, Dr. Bohr-Gosse 7, Vienna A-1030, Austria

Publication History

  1. Published Online: 19 MAR 2002
  2. Published Print: 15 DEC 2000

ISBN Information

Print ISBN: 9780471350545

Online ISBN: 9780471223887

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Keywords:

  • Pax5 (BSAP);
  • B-lineage commitment;
  • gene repression;
  • late B-cell differentiation;
  • PAX5;
  • oncogenic activation;
  • non-Hodgkin's lymphoma

Summary

Here the authors summarize recent experimental data that have provided novel insight into the role of Pax5 in early B-cell development. In addition, they discuss the function of Pax5 in late B-lymphopoiesis based on the analysis of conditional and gain-of-function mutations.

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