Chapter 15. Janus Kinases and STAT Family Transcription Factors: Their Role in the Function and Development of Lymphoid Cells

  1. Katya Ravid3,
  2. Jonathan D. Licht4
  1. Tammy P. Cheng1,
  2. Jérôme Galon2,
  3. Roberta Visconti2,
  4. Massimo Gadina2,
  5. John J. O'Shea2

Published Online: 19 MAR 2002

DOI: 10.1002/0471223883.ch15

Book Title

Transcription Factors: Normal and Malignant Development of Blood Cells

Transcription Factors: Normal and Malignant Development of Blood Cells

Additional Information

How to Cite

Cheng, T. P., Galon, J., Visconti, R., Gadina, M. and O'Shea, J. J. (2002) Janus Kinases and STAT Family Transcription Factors: Their Role in the Function and Development of Lymphoid Cells, in Transcription Factors: Normal and Malignant Development of Blood Cells (eds K. Ravid and J. D. Licht), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223883.ch15

Editor Information

  1. 3

    Department of Biochemistry, Boston University School of Medicine, Boston, MA

  2. 4

    Derald H. Ruttenberg Cancer Center and Department of Medicine, Mount Sinai School of Medicine, New York, NY

Author Information

  1. 1

    Howard Hughes Medical Institute, NIH Research Scholars Program

  2. 2

    NIH, MSC-1820, Building 10, Room 9N252, 10 Center Drive, Bethesda, MD 20892

Publication History

  1. Published Online: 19 MAR 2002
  2. Published Print: 15 DEC 2000

ISBN Information

Print ISBN: 9780471350545

Online ISBN: 9780471223887

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Keywords:

  • Janus kinases (Jaks);
  • Stats;
  • transcription factors;
  • lymphoid cells

Summary

This chapter focuses on only two structurally related families of cytokine receptors, Type I and Type II receptor families, since their receptor phosphorylation leads to the activation of the Stat family of transcription factors. Members of these two receptor families have no intrinsic tyrosine kinase activity and utilize Janus kinases (Jaks) to initiate extracellular signaling. The structure and function of various Jaks and Stats are the focus of this review; the latter in particular are emphasized in accordance with the transcription factor theme of this book.

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