Chapter 16. E2A and the Development of B and T Lymphocytes
- Katya Ravid2,
- Jonathan D. Licht3
Published Online: 19 MAR 2002
DOI: 10.1002/0471223883.ch16
Copyright © 2001 by Wiley-Liss, Inc.
Book Title
Transcription Factors: Normal and Malignant Development of Blood Cells
Additional Information
How to Cite
Kee, B. L. and Murre, C. (2002) E2A and the Development of B and T Lymphocytes, in Transcription Factors: Normal and Malignant Development of Blood Cells (eds K. Ravid and J. D. Licht), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223883.ch16
Editor Information
- 2
Department of Biochemistry, Boston University School of Medicine, Boston, MA
- 3
Derald H. Ruttenberg Cancer Center and Department of Medicine, Mount Sinai School of Medicine, New York, NY
Publication History
- Published Online: 19 MAR 2002
- Published Print: 15 DEC 2000
ISBN Information
Print ISBN: 9780471350545
Online ISBN: 9780471223887
- Summary
- Chapter
Keywords:
- E proteins;
- E2A gene products;
- B lymphocytes;
- T lymphocytes
Summary
In this review the authors focus primarily on the role of one family of transcriptional regulatory proteins, the E proteins, which bind to DNA elements termed E boxes found in the regulatory regions of many lymphocyte-specific genes. The E2A gene, which codes for two proteins E12 and E47, has been shown to play an essential role in B lymphopoiesis and is also required, in combination with other E proteins, for proper T lymphopoiesis. Moreover, recent studies have suggested that E proteins may be instrumental in the establishment of the lineage choice made by multipotent progenitors during the development of the lymphoid lineages.