Chapter 17. The Role of BCL-6 in Normal Lymphoid System and non-Hodgkin's Lymphomas

  1. Katya Ravid2,
  2. Jonathan D. Licht3
  1. B. Hilda Ye

Published Online: 19 MAR 2002

DOI: 10.1002/0471223883.ch17

Book Title

Transcription Factors: Normal and Malignant Development of Blood Cells

Transcription Factors: Normal and Malignant Development of Blood Cells

Additional Information

How to Cite

Ye, B. H. (2002) The Role of BCL-6 in Normal Lymphoid System and non-Hodgkin's Lymphomas, in Transcription Factors: Normal and Malignant Development of Blood Cells (eds K. Ravid and J. D. Licht), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223883.ch17

Editor Information

  1. 2

    Department of Biochemistry, Boston University School of Medicine, Boston, MA

  2. 3

    Derald H. Ruttenberg Cancer Center and Department of Medicine, Mount Sinai School of Medicine, New York, NY

Author Information

  1. Albert Einstein College of Medicine, Department of Cell Biology, Jack & Pearl Resnick Campus, 1300 Morris Park Avenue, Bronx, NY 10461

Publication History

  1. Published Online: 19 MAR 2002
  2. Published Print: 15 DEC 2000

ISBN Information

Print ISBN: 9780471350545

Online ISBN: 9780471223887

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CHAPTER TOOLS

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Keywords:

  • BCL-6 translocations;
  • BCL-6 mutations;
  • BCL-6 expression;
  • BCL-6 protein;
  • BCL-6 function;
  • non-Hodgkin's lymphoma;
  • histogenic marker;
  • B cells;
  • regulation;
  • transcriptional repressor;
  • upstream signals;
  • target genes;
  • interacting proteins;
  • T cells;
  • nonlymphoid cell types

Summary

This chapter reviews findings on BCL-6 translocations and mutations in various types of NHL, mechanisms of its deregulation in lymphomas, and the current understanding of its function in normal as well as tumor B cells. The clinical implications of BCL-6 gene abnormality and protein expression are also discussed.

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